A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

Bioorg Med Chem Lett. 2006 Feb;16(3):718-21. doi: 10.1016/j.bmcl.2005.10.026. Epub 2005 Nov 2.

Abstract

Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.

Publication types

  • Comparative Study

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors
  • 3',5'-Cyclic-AMP Phosphodiesterases / physiology*
  • Chemotaxis / drug effects
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Eosinophils / drug effects
  • Eosinophils / physiology*
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / chemistry
  • Isoenzymes / metabolism
  • Leukocytes / drug effects
  • Leukocytes / physiology*
  • Niacinamide / antagonists & inhibitors*
  • Phosphodiesterase Inhibitors / chemistry
  • Phosphodiesterase Inhibitors / pharmacology*
  • Rolipram / chemistry
  • Rolipram / pharmacology

Substances

  • Isoenzymes
  • Phosphodiesterase Inhibitors
  • Niacinamide
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Rolipram